Juventus were held to a draw by Villarreal in the last 16 first leg, despite Dusan Vlahovic scoring the quickest Champions League debut goal ever.
The 22-year-old Serb, who joined from Fiorentina for £58 million last month, raced onto Danilo’s long pass before swiveling and finishing cleverly after 32 seconds.
Giovani lo Celso of Villarreal clipped a shot just wide of the post.
Dani Parejo equalized with a ghostly finish following Etienne Capoue’s overhead ball into the box.
Juve were fortunate to finish with 11 men, as Adrien Rabiot received only a yellow card for a dangerous tackle on Samuel Chukwueze.
Due to the elimination of the away goal rule this season, the tie is equal heading into the second leg in Turin in three weeks.
Juventus are unbeaten in 90 minutes since November, but they paid the price for their pessimism at the Estadio de la Ceramica.
After scoring in the first minute, they switched to a back five and then switched off when Parejo was left unmarked to fire in a leveler.
Their only other shot on target came from a Vlahovic free kick outside the box in the 85th minute.
To make matters worse, they lost midfielder Weston McKennie in the second half to an ankle injury.
Villarreal, who have never lost at home in the final stages of the Champions League, pressed for a winner but were without injured Spain striker Gerard Moreno.
Arnaut Danjuma, who filled in at the front and scored a hat-trick against Granada on Saturday, had a first-half backheel attempt saved.